Liquid YK-11 10mg/ml, 30ml

Liquid YK-11: A Cutting-Edge SARM for Advanced Research

YK-11 is a groundbreaking selective androgen receptor modulator (SARM) that has gained attention for its unique ability to influence muscle and bone growth. As one of the latest SARMs available for research purposes, YK-11 acts as a gene-specific agonist of the androgen receptor (AR) in MDA-MB 453 cells. Unlike traditional anabolic agents, YK-11 operates through multiple anabolic pathways, demonstrating superior activity in vitro compared to dihydrotestosterone (DHT). It significantly enhances muscle growth by upregulating key myogenic regulatory factors, including myogenic differentiation factor (MyoD) and myogenic factor 5 (Myf5).

What makes YK-11 particularly noteworthy is its oral bioavailability, eliminating the need for injections. Currently, YK-11 is intended solely for laboratory research, and its full range of side effects remains under investigation.

How YK-11 Promotes Muscle Growth

YK-11 stands out due to its ability to modulate follistatin expression, a protein critical for muscle development. Research shows that follistatin enhances insulin-stimulated glucose and amino acid uptake in skeletal muscle cells, improving insulin sensitivity and increasing muscle mass. Additionally, follistatin inhibits catabolic proteins like Activin A, Activin B, and Myostatin, which are known to suppress muscle growth.

While follistatin proteins typically have limited bioavailability and a short half-life, YK-11 stimulates the body to produce follistatin systemically and locally, offering a potential solution to these limitations.

YK-11 for Muscle Wasting and Recovery

Animal studies have explored YK-11’s potential in addressing muscle wasting, particularly in cases of sepsis-induced atrophy. Researchers observed that YK-11 not only protected muscle and organ tissue but also reduced inflammation caused by gram-negative bacteria. In septic mice, YK-11 treatment significantly lowered mortality rates, attributed to its suppression of myostatin and upregulation of follistatin expression.

YK-11 and Bone Growth

YK-11 has also shown promise in promoting bone health. When combined with DHT, YK-11 accelerates cell proliferation and mineralization in MC3T3-E1 mouse osteoblast cells. It upregulates osteoblast-specific markers like osteoprotegerin and osteocalcin, which are essential for bone formation. These effects are mediated through the androgen receptor, as demonstrated by the diminished results when an AR antagonist is introduced.

Further research reveals that YK-11 activates non-genomic signaling via Akt protein phosphorylation, a key pathway in androgen-mediated osteoblast differentiation. This makes YK-11 a compelling candidate for future studies in bone tissue engineering.

Potential Side Effects of YK-11

While clinical data on YK-11’s side effects is limited, anecdotal reports suggest possible joint pain, mild male-pattern hair loss, acne, and increased aggression. Given its action on the androgen receptor, YK-11 may also share side effects commonly associated with other anabolic agents, such as elevated hemoglobin, high blood pressure, insomnia, nausea, or liver strain. It is crucial to note that YK-11 is strictly for research purposes and is not approved for human consumption.

Liquid YK-11 Product Details

• CAS Number: 1370003-76-1
• Molecular Formula: C25H34O6
• Molar Mass: 430.541 g/mol
• Class: Myostatin Inhibitor, Selective Androgen Receptor Modulator (SARM)
• Storage Instructions: Store in a cool, dry place away from direct sunlight to preserve stability.

Each 50ml Bottle Contains:

• 10mg/ml of YK-11
• Graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for safety during transit
• Less than 5% concentration variance for consistent results
• Formulated to prevent evaporation during storage

Disclaimer: This product is designed exclusively for laboratory research and is not approved by the FDA for human consumption. YK-11 is not a dietary or sports supplement.

References:

1. YK-11 as a partial agonist of the androgen receptor. PubMed
2. YK-11 regulates myogenic differentiation via follistatin expression. PubMed
3. Follistatin’s role in muscle hypertrophy and insulin action. Wiley Online Library
4. YK-11’s protective effects against sepsis-induced muscle wasting. ScienceDirect
5. YK-11’s impact on osteoblast proliferation and differentiation. JStage

Disclaimer: This product is intended for research purposes only. It is not intended for human consumption, medical treatment, or therapeutic use without professional oversight.