Liquid Testolone (RAD-140) 20mg/ml, 30ml

Liquid RAD-140 (Testolone) Overview – Elitebiogenix.com

RAD-140, commonly referred to as Testolone, is a cutting-edge selective androgen receptor modulator (SARM) originally designed as a potential alternative to traditional testosterone replacement therapies. Distinct from its esterified counterpart, RAD-150 (TLB-150), RAD-140 selectively binds to androgen receptors (AR) without triggering the full spectrum of androgenic effects associated with testosterone, DHT, or anabolic steroids. This unique mechanism makes it a popular choice for research purposes, particularly in studies focused on muscle growth, neuroprotection, and cellular health.

Why RAD-140 Stands Out: High AR Binding Affinity

RAD-140 boasts an exceptional affinity for androgen receptors (AR), with a Ki value of 7 nM, surpassing even DHT and many anabolic steroids. For comparison, testosterone has an AR affinity of 29 nM, while DHT registers at 10 nM. Unlike traditional anabolic agents, RAD-140 is orally bioavailable, eliminating the need for injections. This feature, combined with its potent anabolic properties, has made it a standout SARM for researchers exploring muscle mass enhancement and lean body composition.

Developed in 2010, RAD-140 was initially studied for its potential in treating osteoporosis and promoting muscle growth. Subsequent preclinical trials on primates and rodents, as well as clinical studies, have revealed additional therapeutic benefits, further solidifying its position as a versatile research compound.

RAD-140 and Muscle Growth: What Research Shows

A study involving young male cynomolgus monkeys examined the effects of RAD-140 over 28 days at doses of 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg daily. The results showed a 10% increase in body weight in the 0.1 mg/kg and 1 mg/kg groups, with no additional benefits observed at higher doses. Notably, muscle mass increased significantly in these groups, while body fat remained unchanged. Importantly, there were no adverse effects on liver enzymes or prostate weight, highlighting RAD-140’s selective action on muscle tissue.

Neuroprotective Benefits of RAD-140

RAD-140 has demonstrated promising neuroprotective properties in both in vitro and in vivo studies. A 2014 study found that RAD-140 prevented cell death and restored mitochondrial membrane potential in cultured neurons. In animal models, it significantly reduced seizure activity in male rats with kainate-induced lesions, suggesting potential applications in treating neurological disorders.

Additionally, RAD-140 has shown promise in addressing cognitive decline. Research indicates that androgens, including RAD-140, can inhibit neuronal apoptosis and improve cognitive function, particularly in Alzheimer’s disease (AD) models. By activating rapid phosphoinositide 3-kinase/Akt signaling, RAD-140 regulates proteins linked to apoptosis, such as bax, seladin 1, survivin, XIAP, and bcl-xl, offering a potential pathway for neuroprotection.

RAD-140 and Cellular Protection

Studies have also explored RAD-140’s role in cellular protection. In animal models, RAD-140 replicated the muscle growth benefits of testosterone at half the androgenic activity, making it a safer alternative for research purposes. Its ability to protect neurons and reduce seizure activity further underscores its potential in treating neurodegenerative conditions.

RAD-140 and Breast Cancer: A Promising Avenue

A 2017 study investigated RAD-140’s effects on AR/ER+ breast cancer cells. The results were groundbreaking: RAD-140 significantly inhibited cancer cell growth and metastasis without disrupting the cell cycle. Unlike traditional anti-estrogens and aromatase inhibitors, RAD-140 operates through distinct mechanisms, offering a novel therapeutic approach for hormone-sensitive breast cancers. While more research is needed, these findings position RAD-140 as a potential game-changer in oncology.

Mechanism of Action: How RAD-140 Works

RAD-140’s mechanism of action is multifaceted, offering a range of potential benefits in preclinical studies:

• Increased lean muscle mass and protein synthesis
• Enhanced fat loss and body recomposition
• Neuroprotection and reduced beta-amyloid plaques
• Potential anti-cancer properties
• Improved endurance and recovery

It’s important to note that RAD-140 is not approved by the FDA for human use and is strictly intended for laboratory research. Anecdotal reports suggest potential side effects, including testosterone suppression, nausea, and mild hair loss, though further studies are needed to confirm these findings.

Potential Side Effects of RAD-140

While RAD-140 is generally well-tolerated in research settings, some studies have reported side effects such as nausea, aggression, and reduced natural testosterone levels. A case study highlighted drug-induced liver injury in a subject using RAD-140 alongside antidepressants, though the sample size and lack of controls limit the conclusions. As with all SARMs, RAD-140 may suppress natural testosterone production, emphasizing the need for cautious use in research contexts.

Liquid RAD-140 Specifications – Elitebiogenix.com

• CAS Number: 1182367-47-0
• Molecular Formula: C20H16ClN5O2
• Molar Mass: 393.83 g/mol
• Half-Life: 44.7 hours
• Class: Selective Androgen Receptor Modulator (SARM)
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Each 30ml bottle contains 20 mg/ml of RAD-140, accompanied by a graduated 1mL glass pipette for precise measurement. The UV-resistant glass bottle and tamper-proof seal ensure product integrity and safety during transit. With less than 5% variance in concentration, Elitebiogenix guarantees consistency and quality in every batch.

Disclaimer:
RAD-140 is intended solely for laboratory research purposes and is not approved for human consumption. It is not a dietary or sports supplement. Elitebiogenix adheres to strict quality standards to provide researchers with reliable, high-quality compounds for scientific exploration.

References:

1. Design, Synthesis, and Preclinical Characterization of RAD140 – PubMed
2. Neuroprotective Effects of RAD140 – Endocrinology Journal
3. RAD140 and Breast Cancer – Clinical Cancer Research
4. Androgens and Cognitive Function – Endocrinology Journal
5. Drug-Induced Liver Injury and SARMs – Hepatology Journal

Explore the potential of RAD-140 with Elitebiogenix – your trusted source for premium research compounds.