MK-677, Ostarine & RAD-140

(18-35 year old demographic)

MK-677 (Ibutamoren) Overview – EliteBiogenix.com

MK-677, also known as Ibutamoren, Nutrobal, or Oratrope, is a potent ghrelin receptor agonist and growth hormone secretagogue. With a molecular weight of 528.662, MK-677 stimulates the pituitary gland to release human growth hormone (HGH) and is often grouped with selective androgen receptor modulators (SARMs). Unlike ghrelin, MK-677 is not a peptide but a spiropiperidine compound. Its ability to cross the blood-brain barrier allows it to function as a neuropeptide within the central nervous system, making it a unique and powerful compound.

How MK-677 Stands Out Among Growth Hormone Secretagogues

MK-677 is a highly effective growth hormone stimulant, often found alongside SARMs in research catalogs. Unlike other compounds like GHRP-6 and GHRP-2, MK-677 elevates insulin-like growth factor 1 (IGF-1) levels for up to 24 hours after a single dose without disrupting the body’s natural pulsatile GH release. Since it does not interact with androgen receptors, MK-677 may improve body composition without negatively affecting testosterone or other endogenous androgens. Research also suggests that MK-677 may work synergistically with growth hormone-releasing peptides such as Tesamorelin and Ipamorelin, enhancing its potential benefits.

How MK-677 Works

MK-677 mimics the action of ghrelin, the hunger hormone, to stimulate the release of growth hormone and IGF-1. Unlike many growth hormone peptides, MK-677 is orally bioavailable, eliminating the need for injections. This makes it a convenient option for researchers. At EliteBiogenix.com, we offer premium MK-677 with verified purity, fast shipping, secure payment processing, and exceptional customer support, making us the trusted source for high-quality research compounds.

Clinically Researched Benefits of MK-677

Extensive studies have demonstrated the potential benefits of MK-677, including:

• Increased growth hormone and IGF-1 levels
• Enhanced muscle mass and lean body composition
• Reduced body fat
• Improved bone density
• Accelerated muscle recovery and growth
• Strengthened immune function
• Better REM sleep quality
• Increased appetite
• Reversal of growth hormone deficiency
• Potential neuroprotective effects against beta-amyloid buildup

Key Findings from MK-677 Studies

1. Growth Hormone Release: Research shows that MK-677 significantly increases IGF-1 and IGF-binding protein-3 (IGFBP-3) levels, making it a promising option for addressing growth hormone deficiencies and supporting muscle growth.
2. Body Composition: Clinical trials have found that MK-677 improves bone mineral density, muscle mass, and overall body composition in older adults. A randomized controlled trial also noted enhanced nitrogen retention, even during calorie restriction, suggesting its potential for preserving muscle mass in challenging conditions.
3. Sleep Quality: Studies indicate that MK-677 improves REM sleep duration and reduces REM latency, particularly in older adults. Enhanced stage 4 sleep, crucial for tissue repair, further highlights its potential for recovery and neurological health.
4. Chronic Disease Potential: Animal studies suggest that MK-677 may reduce neuroinflammation, neurodegeneration, and beta-amyloid buildup, offering potential preventive benefits against conditions like Alzheimer’s disease. However, more human studies are needed to confirm these findings.

Potential Side Effects of MK-677

While MK-677 shows promise, it is important to note that it is not FDA-approved for human consumption. Reported side effects include water retention, changes in blood pressure, and increased appetite due to its ghrelin-mimetic properties. Long-term use may also risk desensitizing ghrelin receptors. MK-677 is strictly for research purposes and should be handled with caution.

MK-677 Product Details

• CAS Number: 159752-10-0
• Chemical Formula: C27H36N4O5S
• Molar Mass: 528.662 g/mol
• Half-Life: 24 hours
• Class: Ghrelin Receptor Agonist, Growth Hormone Secretagogue
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Product Specifications:

• 50ml liquid MK-677 per bottle (25mg/ml concentration)
• Includes a graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for safety
• Less than 5% concentration variance for consistency
• Formulated to prevent evaporation during storage

Disclaimer: MK-677 is a research chemical intended for laboratory use only. It is not approved for human consumption, dietary use, or as a sports supplement.

References:

1. Oral administration of MK-677 increases markers of bone turnover in elderly adults. PubMed
2. Design and biological activities of MK-677. PubMed
3. MK-677 stimulates the GH/IGF-1 axis in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism
4. MK-677 improves sleep quality in humans. PubMed
5. MK-677 reverses diet-induced catabolism. PubMed
6. MK-677 alleviates amyloid-beta pathology in Alzheimer’s models. PubMed

Why Choose EliteBiogenix.com for MK-677?
At EliteBiogenix.com, we prioritize quality, safety, and customer satisfaction. Our MK-677 is rigorously tested for purity and consistency, ensuring reliable results for your research needs. With fast shipping, secure payment options, and dedicated support, we are your trusted partner in advanced research compounds.

Explore the potential of MK-677 today – exclusively at EliteBiogenix.com!

(18-35 year old demographic)

LIQUID OSTARINE (MK-2866) – THE ULTIMATE GUIDE

Ostarine, also known as MK-2866, GTX-024, or Enobosarm, is one of the most well-researched and widely recognized selective androgen receptor modulators (SARMs). Originally developed in the late 1990s, Ostarine was designed as a potential treatment for conditions like osteoporosis, muscle wasting, and insulin resistance. Today, it remains a focal point of clinical research due to its unique ability to selectively target androgen receptors without the harsh side effects commonly associated with anabolic steroids, testosterone, or human growth hormone.

WHY OSTARINE STANDS OUT IN CLINICAL RESEARCH

Ostarine’s selective action makes it a promising candidate for research, particularly in female and elderly populations where traditional anabolic treatments may not be suitable. Studies have shown that Ostarine is generally well-tolerated, with doses of up to 18mg per day administered safely over 12 months in female cancer patients. Unlike many anabolic agents, Ostarine is orally bioavailable, eliminating the need for injections.

While Ostarine shows significant potential, it’s important to note that research is ongoing. Potential side effects, such as testosterone suppression in males and menstrual irregularities in females, are still being studied. Long-term effects and interactions with other substances remain under investigation.

POTENTIAL BENEFITS OF OSTARINE IN RESEARCH STUDIES

Research on Ostarine has highlighted several potential benefits, including:

• Enhanced muscle growth and strength
• Increased protein synthesis
• Improved bone density and health
• Accelerated recovery of connective tissues
• Reduction in body fat and support for weight loss
• Boosted energy levels
• Positive effects on heart health

It’s crucial to emphasize that Ostarine is not approved by the FDA for human consumption and is strictly intended for laboratory research purposes. It should not be confused with dietary supplements or sports performance enhancers.

KEY RESEARCH FINDINGS ON OSTARINE (MK-2866)

1. Muscle and Strength Benefits: A 2011 study demonstrated that Ostarine significantly increased lean body mass, muscle strength, and physical function in elderly men and postmenopausal women.
2. Bone Health: A 2019 study on ovariectomized rats found that Ostarine improved bone healing and stimulated muscle growth.
3. Fat Metabolism: Research on Wistar rats revealed that Ostarine reduced fat-mediating hormones like leptin, suggesting potential benefits for fat loss.
4. Osteoporosis Support: Another 2019 study showed that Ostarine increased bone mineral density and reduced osteoporosis symptoms in postmenopausal rat models.

POTENTIAL SIDE EFFECTS AND SAFETY CONSIDERATIONS

As one of the oldest and most studied SARMs, Ostarine has a well-documented profile. However, research is still uncovering its full range of effects. Potential side effects may include:

• Testosterone suppression in males
• Menstrual irregularities in females
• Possible liver strain or increased hematocrit levels
• Insomnia or lethargy in some cases

The FDA has issued warnings about the misuse of Ostarine, emphasizing that it is not approved for human use and may pose serious health risks if abused.

LIQUID OSTARINE (MK-2866) PRODUCT DETAILS

• CAS Number: 841205-47-8
• Molecular Formula: C19H14F3N3O3
• Molar Mass: 389.330 g/mol
• Half-Life: 24 hours
• Classification: Selective Androgen Receptor Modulator (SARM)

Product Specifications:

• 30ml liquid Ostarine per bottle
• Concentration: 25mg per milliliter
• Includes a graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for safety during transit
• Less than 5% variance in concentration for consistent results
• Formulated to prevent evaporation during storage

Storage Instructions: Store in a cool, dry place away from direct sunlight to maintain optimal shelf life.

Disclaimer: This product is intended for laboratory research purposes only. It is not approved for human consumption, nor is it a dietary or sports supplement.

REFERENCES

1. Dalton JT, et al. (2011). The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women. PubMed.
2. Hoffmann DB, et al. (2019). Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis. PubMed.
3. Smith MR, et al. (2019). A Phase II Clinical Trial of Pembrolizumab and Enobosarm in Patients with Androgen Receptor-Positive Metastatic Triple-Negative Breast Cancer. PubMed.
4. Effect of ostarine (enobosarm/GTX024) on adipocyte metabolism in Wistar rats. PubMed.

(18-35 year old demographic)

Liquid RAD-140 (Testolone) Overview – Elitebiogenix.com

RAD-140, commonly referred to as Testolone, is a cutting-edge selective androgen receptor modulator (SARM) originally designed as a potential alternative to traditional testosterone replacement therapies. Distinct from its esterified counterpart, RAD-150 (TLB-150), RAD-140 selectively binds to androgen receptors (AR) without triggering the full spectrum of androgenic effects associated with testosterone, DHT, or anabolic steroids. This unique mechanism makes it a popular choice for research purposes, particularly in studies focused on muscle growth, neuroprotection, and cellular health.

Why RAD-140 Stands Out: High AR Binding Affinity

RAD-140 boasts an exceptional affinity for androgen receptors (AR), with a Ki value of 7 nM, surpassing even DHT and many anabolic steroids. For comparison, testosterone has an AR affinity of 29 nM, while DHT registers at 10 nM. Unlike traditional anabolic agents, RAD-140 is orally bioavailable, eliminating the need for injections. This feature, combined with its potent anabolic properties, has made it a standout SARM for researchers exploring muscle mass enhancement and lean body composition.

Developed in 2010, RAD-140 was initially studied for its potential in treating osteoporosis and promoting muscle growth. Subsequent preclinical trials on primates and rodents, as well as clinical studies, have revealed additional therapeutic benefits, further solidifying its position as a versatile research compound.

RAD-140 and Muscle Growth: What Research Shows

A study involving young male cynomolgus monkeys examined the effects of RAD-140 over 28 days at doses of 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg daily. The results showed a 10% increase in body weight in the 0.1 mg/kg and 1 mg/kg groups, with no additional benefits observed at higher doses. Notably, muscle mass increased significantly in these groups, while body fat remained unchanged. Importantly, there were no adverse effects on liver enzymes or prostate weight, highlighting RAD-140’s selective action on muscle tissue.

Neuroprotective Benefits of RAD-140

RAD-140 has demonstrated promising neuroprotective properties in both in vitro and in vivo studies. A 2014 study found that RAD-140 prevented cell death and restored mitochondrial membrane potential in cultured neurons. In animal models, it significantly reduced seizure activity in male rats with kainate-induced lesions, suggesting potential applications in treating neurological disorders.

Additionally, RAD-140 has shown promise in addressing cognitive decline. Research indicates that androgens, including RAD-140, can inhibit neuronal apoptosis and improve cognitive function, particularly in Alzheimer’s disease (AD) models. By activating rapid phosphoinositide 3-kinase/Akt signaling, RAD-140 regulates proteins linked to apoptosis, such as bax, seladin 1, survivin, XIAP, and bcl-xl, offering a potential pathway for neuroprotection.

RAD-140 and Cellular Protection

Studies have also explored RAD-140’s role in cellular protection. In animal models, RAD-140 replicated the muscle growth benefits of testosterone at half the androgenic activity, making it a safer alternative for research purposes. Its ability to protect neurons and reduce seizure activity further underscores its potential in treating neurodegenerative conditions.

RAD-140 and Breast Cancer: A Promising Avenue

A 2017 study investigated RAD-140’s effects on AR/ER+ breast cancer cells. The results were groundbreaking: RAD-140 significantly inhibited cancer cell growth and metastasis without disrupting the cell cycle. Unlike traditional anti-estrogens and aromatase inhibitors, RAD-140 operates through distinct mechanisms, offering a novel therapeutic approach for hormone-sensitive breast cancers. While more research is needed, these findings position RAD-140 as a potential game-changer in oncology.

Mechanism of Action: How RAD-140 Works

RAD-140’s mechanism of action is multifaceted, offering a range of potential benefits in preclinical studies:

• Increased lean muscle mass and protein synthesis
• Enhanced fat loss and body recomposition
• Neuroprotection and reduced beta-amyloid plaques
• Potential anti-cancer properties
• Improved endurance and recovery

It’s important to note that RAD-140 is not approved by the FDA for human use and is strictly intended for laboratory research. Anecdotal reports suggest potential side effects, including testosterone suppression, nausea, and mild hair loss, though further studies are needed to confirm these findings.

Potential Side Effects of RAD-140

While RAD-140 is generally well-tolerated in research settings, some studies have reported side effects such as nausea, aggression, and reduced natural testosterone levels. A case study highlighted drug-induced liver injury in a subject using RAD-140 alongside antidepressants, though the sample size and lack of controls limit the conclusions. As with all SARMs, RAD-140 may suppress natural testosterone production, emphasizing the need for cautious use in research contexts.

Liquid RAD-140 Specifications – Elitebiogenix.com

• CAS Number: 1182367-47-0
• Molecular Formula: C20H16ClN5O2
• Molar Mass: 393.83 g/mol
• Half-Life: 44.7 hours
• Class: Selective Androgen Receptor Modulator (SARM)
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Each 30ml bottle contains 20 mg/ml of RAD-140, accompanied by a graduated 1mL glass pipette for precise measurement. The UV-resistant glass bottle and tamper-proof seal ensure product integrity and safety during transit. With less than 5% variance in concentration, Elitebiogenix guarantees consistency and quality in every batch.

Disclaimer:
RAD-140 is intended solely for laboratory research purposes and is not approved for human consumption. It is not a dietary or sports supplement. Elitebiogenix adheres to strict quality standards to provide researchers with reliable, high-quality compounds for scientific exploration.

References:

1. Design, Synthesis, and Preclinical Characterization of RAD140 – PubMed
2. Neuroprotective Effects of RAD140 – Endocrinology Journal
3. RAD140 and Breast Cancer – Clinical Cancer Research
4. Androgens and Cognitive Function – Endocrinology Journal
5. Drug-Induced Liver Injury and SARMs – Hepatology Journal

Explore the potential of RAD-140 with Elitebiogenix – your trusted source for premium research compounds.