MK-677, YK-11 & LGD-4033

(18-35 year old demographic)

MK-677 (Ibutamoren) Overview – EliteBiogenix.com

MK-677, also known as Ibutamoren, Nutrobal, or Oratrope, is a potent ghrelin receptor agonist and growth hormone secretagogue. With a molecular weight of 528.662, MK-677 stimulates the pituitary gland to release human growth hormone (HGH) and is often grouped with selective androgen receptor modulators (SARMs). Unlike ghrelin, MK-677 is not a peptide but a spiropiperidine compound. Its ability to cross the blood-brain barrier allows it to function as a neuropeptide within the central nervous system, making it a unique and powerful compound.

How MK-677 Stands Out Among Growth Hormone Secretagogues

MK-677 is a highly effective growth hormone stimulant, often found alongside SARMs in research catalogs. Unlike other compounds like GHRP-6 and GHRP-2, MK-677 elevates insulin-like growth factor 1 (IGF-1) levels for up to 24 hours after a single dose without disrupting the body’s natural pulsatile GH release. Since it does not interact with androgen receptors, MK-677 may improve body composition without negatively affecting testosterone or other endogenous androgens. Research also suggests that MK-677 may work synergistically with growth hormone-releasing peptides such as Tesamorelin and Ipamorelin, enhancing its potential benefits.

How MK-677 Works

MK-677 mimics the action of ghrelin, the hunger hormone, to stimulate the release of growth hormone and IGF-1. Unlike many growth hormone peptides, MK-677 is orally bioavailable, eliminating the need for injections. This makes it a convenient option for researchers. At EliteBiogenix.com, we offer premium MK-677 with verified purity, fast shipping, secure payment processing, and exceptional customer support, making us the trusted source for high-quality research compounds.

Clinically Researched Benefits of MK-677

Extensive studies have demonstrated the potential benefits of MK-677, including:

• Increased growth hormone and IGF-1 levels
• Enhanced muscle mass and lean body composition
• Reduced body fat
• Improved bone density
• Accelerated muscle recovery and growth
• Strengthened immune function
• Better REM sleep quality
• Increased appetite
• Reversal of growth hormone deficiency
• Potential neuroprotective effects against beta-amyloid buildup

Key Findings from MK-677 Studies

1. Growth Hormone Release: Research shows that MK-677 significantly increases IGF-1 and IGF-binding protein-3 (IGFBP-3) levels, making it a promising option for addressing growth hormone deficiencies and supporting muscle growth.
2. Body Composition: Clinical trials have found that MK-677 improves bone mineral density, muscle mass, and overall body composition in older adults. A randomized controlled trial also noted enhanced nitrogen retention, even during calorie restriction, suggesting its potential for preserving muscle mass in challenging conditions.
3. Sleep Quality: Studies indicate that MK-677 improves REM sleep duration and reduces REM latency, particularly in older adults. Enhanced stage 4 sleep, crucial for tissue repair, further highlights its potential for recovery and neurological health.
4. Chronic Disease Potential: Animal studies suggest that MK-677 may reduce neuroinflammation, neurodegeneration, and beta-amyloid buildup, offering potential preventive benefits against conditions like Alzheimer’s disease. However, more human studies are needed to confirm these findings.

Potential Side Effects of MK-677

While MK-677 shows promise, it is important to note that it is not FDA-approved for human consumption. Reported side effects include water retention, changes in blood pressure, and increased appetite due to its ghrelin-mimetic properties. Long-term use may also risk desensitizing ghrelin receptors. MK-677 is strictly for research purposes and should be handled with caution.

MK-677 Product Details

• CAS Number: 159752-10-0
• Chemical Formula: C27H36N4O5S
• Molar Mass: 528.662 g/mol
• Half-Life: 24 hours
• Class: Ghrelin Receptor Agonist, Growth Hormone Secretagogue
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Product Specifications:

• 30ml liquid MK-677 per bottle (25mg/ml concentration)
• Includes a graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for safety
• Less than 5% concentration variance for consistency
• Formulated to prevent evaporation during storage

Disclaimer: MK-677 is a research chemical intended for laboratory use only. It is not approved for human consumption, dietary use, or as a sports supplement.

References:

1. Oral administration of MK-677 increases markers of bone turnover in elderly adults. PubMed
2. Design and biological activities of MK-677. PubMed
3. MK-677 stimulates the GH/IGF-1 axis in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism
4. MK-677 improves sleep quality in humans. PubMed
5. MK-677 reverses diet-induced catabolism. PubMed
6. MK-677 alleviates amyloid-beta pathology in Alzheimer’s models. PubMed

Why Choose EliteBiogenix.com for MK-677?
At EliteBiogenix.com, we prioritize quality, safety, and customer satisfaction. Our MK-677 is rigorously tested for purity and consistency, ensuring reliable results for your research needs. With fast shipping, secure payment options, and dedicated support, we are your trusted partner in advanced research compounds.

Explore the potential of MK-677 today – exclusively at EliteBiogenix.com!

(18-35 year old demographic)

Liquid YK-11: A Cutting-Edge SARM for Advanced Research

YK-11 is a groundbreaking selective androgen receptor modulator (SARM) that has gained attention for its unique ability to influence muscle and bone growth. As one of the latest SARMs available for research purposes, YK-11 acts as a gene-specific agonist of the androgen receptor (AR) in MDA-MB 453 cells. Unlike traditional anabolic agents, YK-11 operates through multiple anabolic pathways, demonstrating superior activity in vitro compared to dihydrotestosterone (DHT). It significantly enhances muscle growth by upregulating key myogenic regulatory factors, including myogenic differentiation factor (MyoD) and myogenic factor 5 (Myf5).

What makes YK-11 particularly noteworthy is its oral bioavailability, eliminating the need for injections. Currently, YK-11 is intended solely for laboratory research, and its full range of side effects remains under investigation.

How YK-11 Promotes Muscle Growth

YK-11 stands out due to its ability to modulate follistatin expression, a protein critical for muscle development. Research shows that follistatin enhances insulin-stimulated glucose and amino acid uptake in skeletal muscle cells, improving insulin sensitivity and increasing muscle mass. Additionally, follistatin inhibits catabolic proteins like Activin A, Activin B, and Myostatin, which are known to suppress muscle growth.

While follistatin proteins typically have limited bioavailability and a short half-life, YK-11 stimulates the body to produce follistatin systemically and locally, offering a potential solution to these limitations.

YK-11 for Muscle Wasting and Recovery

Animal studies have explored YK-11’s potential in addressing muscle wasting, particularly in cases of sepsis-induced atrophy. Researchers observed that YK-11 not only protected muscle and organ tissue but also reduced inflammation caused by gram-negative bacteria. In septic mice, YK-11 treatment significantly lowered mortality rates, attributed to its suppression of myostatin and upregulation of follistatin expression.

YK-11 and Bone Growth

YK-11 has also shown promise in promoting bone health. When combined with DHT, YK-11 accelerates cell proliferation and mineralization in MC3T3-E1 mouse osteoblast cells. It upregulates osteoblast-specific markers like osteoprotegerin and osteocalcin, which are essential for bone formation. These effects are mediated through the androgen receptor, as demonstrated by the diminished results when an AR antagonist is introduced.

Further research reveals that YK-11 activates non-genomic signaling via Akt protein phosphorylation, a key pathway in androgen-mediated osteoblast differentiation. This makes YK-11 a compelling candidate for future studies in bone tissue engineering.

Potential Side Effects of YK-11

While clinical data on YK-11’s side effects is limited, anecdotal reports suggest possible joint pain, mild male-pattern hair loss, acne, and increased aggression. Given its action on the androgen receptor, YK-11 may also share side effects commonly associated with other anabolic agents, such as elevated hemoglobin, high blood pressure, insomnia, nausea, or liver strain. It is crucial to note that YK-11 is strictly for research purposes and is not approved for human consumption.

Liquid YK-11 Product Details

• CAS Number: 1370003-76-1
• Molecular Formula: C25H34O6
• Molar Mass: 430.541 g/mol
• Class: Myostatin Inhibitor, Selective Androgen Receptor Modulator (SARM)
• Storage Instructions: Store in a cool, dry place away from direct sunlight to preserve stability.

Each 50ml Bottle Contains:

• 10mg/ml of YK-11
• Graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for safety during transit
• Less than 5% concentration variance for consistent results
• Formulated to prevent evaporation during storage

Disclaimer: This product is designed exclusively for laboratory research and is not approved by the FDA for human consumption. YK-11 is not a dietary or sports supplement.

References:

1. YK-11 as a partial agonist of the androgen receptor. PubMed
2. YK-11 regulates myogenic differentiation via follistatin expression. PubMed
3. Follistatin’s role in muscle hypertrophy and insulin action. Wiley Online Library
4. YK-11’s protective effects against sepsis-induced muscle wasting. ScienceDirect
5. YK-11’s impact on osteoblast proliferation and differentiation. JStage

(18-35 year old demographic)

Premium Liquid LGD-4033 (Ligandrol) for Sale – EliteBiogenix.com

Looking for high-quality LGD-4033 (Ligandrol)? EliteBiogenix offers premium liquid LGD-4033, a cutting-edge Selective Androgen Receptor Modulator (SARM) designed to support muscle growth, bone recovery, and lean body mass development. Known for its high selectivity and minimal side effects, LGD-4033 is a top choice for researchers and fitness enthusiasts alike.

What is LGD-4033 (Ligandrol)?

LGD-4033, also referred to as Ligandrol, is a third-generation non-steroidal SARM with a strong affinity for androgen receptors (Ki of ~1 nM). Unlike traditional anabolic steroids, LGD-4033 selectively targets receptors in muscle, bone, and connective tissues, while showing minimal interaction with receptors in the prostate, scalp, and skin. This makes it a safer alternative for achieving lean muscle mass without the unwanted side effects of steroids.

Originally developed by Ligand Pharmaceuticals, LGD-4033 was designed to address conditions like muscle wasting and osteoporosis. Its ability to promote muscle growth and bone recovery has made it one of the most popular SARMs on the market today.

Key Benefits of LGD-4033

1. Supports Lean Muscle Growth:
   Preclinical studies on primates demonstrated significant dose-dependent increases in lean body mass over a 13-week period. Notably, 70% of the gained muscle mass was retained even after a 4-week recovery period.
2. Enhances Bone Recovery:
   Clinical trials involving 120 patients recovering from hip fracture surgery showed that LGD-4033 significantly improved bone anabolism markers (e.g., serum procollagen type 1 propeptide) and increased lean body mass while reducing fat mass.
3. Minimal Side Effects:
   In Phase 1 and Phase 2 clinical trials, LGD-4033 was well-tolerated by participants, with no significant adverse effects reported.

Why Choose EliteBiogenix Liquid LGD-4033?

Our liquid LGD-4033 is formulated for precision and quality, ensuring optimal results for research purposes. Here’s what sets us apart:

• High Purity: Each bottle contains 30ml of liquid LGD-4033 with a concentration of 10mg per milliliter.
• Accurate Measurement: Includes a graduated 1mL glass pipette for precise dosing.
• Premium Packaging: UV-resistant glass bottle with a tamper-proof seal to ensure safety and longevity.
• Consistency Guaranteed: Less than 5% variance in concentration for reliable results.
• Long Shelf Life: Store in a cool, dry place away from direct sunlight to maintain potency.

Note: This product is intended for laboratory research purposes only and is not approved for human consumption or use as a dietary/sports supplement.

Product Specifications

• CAS Number: 1165910-22-4
• Molecular Formula: C14H12F6N2O
• Molar Mass: 338.258 g/mol
• Half-Life: 24–36 hours
• Class: Selective Androgen Receptor Modulator (SARM)

Scientific References

1. Basaria, S., et al. (2013). The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. PubMed
2. Fragkaki, A.G., et al. (2020). Human in vivo metabolism study of LGD-4033. Drug Test Analysis
3. Viking Therapeutics. Phase 2 Trial of VK5211 in Patients Recovering From Hip Fracture. Team Olympus Blog