PT-141 & MT2

(18-35 year old demographic)

PT 141 Overview
PT 141, also referred to as Bremelanotide, is a cutting-edge peptide that primarily targets the Melanocortin 4 receptor (MC4-R) within the central nervous system, promoting sexual arousal. Research conducted on animal models has demonstrated that PT 141 effectively binds to MC4-R, enhancing sexual activity in both males and females. At EliteBioGenix, we provide high-quality PT 141 peptides for laboratory research, ensuring purity and reliability for scientific studies.

PT 141 for Sexual Health and Dysfunction
PT 141 shows significant potential as a therapeutic option for sexual disorders unrelated to blood flow issues. Unlike traditional erectile dysfunction treatments, PT 141 has been shown to induce erections in males who do not respond to conventional medications. Its unique mechanism of action makes it a promising candidate for addressing sexual dysfunction and improving overall sexual health.

Potential Medical Applications of PT 141

1. Hemorrhagic Shock and Enhanced Blood Flow
PT 141 is under investigation for its role in treating hemorrhagic shock. By binding to MC1-R and MC4-R receptors, it enhances blood supply to tissues, potentially preventing damage during reduced blood flow scenarios. Intravenous studies have shown minimal side effects, highlighting its safety profile.

2. Anti-Fungal and Anti-Inflammatory Properties
Recent animal studies suggest that MC1-R activation can combat fungal infections while reducing inflammation. Although further research is needed, this indicates PT 141’s potential as a novel treatment for fungal infections and inflammatory conditions, particularly in individuals with autoimmune diseases.

3. Cancer Prevention and Therapy
Variants of MC1-R have been linked to an increased risk of skin cancers, such as basal cell and squamous cell carcinoma. However, MC1-R also stimulates DNA repair pathways, offering potential applications in cancer prevention and treatment.

4. Weight Loss and Metabolic Benefits
PT 141, along with similar peptides like Melanotan II, activates MC4-R, which promotes satiety and reduces calorie intake. Animal studies indicate that PT 141 can boost energy expenditure and improve metabolic function, making it a potential aid in weight management. Clinical trials have shown that subjects administered PT 141 experienced significantly greater weight loss compared to placebo groups.

PT 141 Research Data

• CAS Number: 1607799-13-2
• Molecular Formula: C50H68N14O10
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molar Mass: 1025.182 g/mol
• Half-Life: 2.7 hours
• Class: Cyclic Heptapeptide

Storage and Usage Instructions

• Store reconstituted PT 141 under refrigeration.
• Each vial contains a lyophilized sample with a minimum purity of 96% (including stabilizing agents).
• 10mg of PT 141 per vial.
• Diluent and laboratory supplies are not included.

Important Note:
This product is intended solely for in vitro laboratory research by qualified professionals. It is not approved by the FDA for human or animal consumption and should not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.

References:

1. Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice. PubMed
2. Evaluation of PT-141 safety and pharmacokinetics in healthy males and patients with inadequate response to Viagra. PubMed
3. PT-141 induces penile erection via brain and spinal melanocortin receptors. PubMed
4. Melanotan II enhances proceptive sexual behaviors in female rats. PubMed
5. Bremelanotide as a salvage treatment for sildenafil failures. PubMed
6. Anti-fungal and anti-inflammatory effects of melanocortin against Candida albicans. PubMed
7. Skin cancer risks associated with MC1-R variants. PubMed
8. Skin phototype and melanocortin receptor activity. PubMed
9. Melanotan II and thermogenic capacity in mice. PubMed
10. Bremelanotide’s effect on body weight in obese women. PubMed

(18-35 year old demographic)

Melanotan 2 (10mg) – Comprehensive Overview and Benefits

What is Melanotan 2?
Melanotan 2 (MT-2) is a lab-created peptide designed to mimic the effects of the natural hormone alpha-melanocyte-stimulating hormone (α-MSH). This innovative compound has been studied for its potential benefits, including enhancing skin pigmentation (melanogenesis), boosting libido, aiding in weight management, reducing compulsive behaviors, and even showing promise in addressing symptoms associated with Autism Spectrum Disorder (ASD).

Melanotan 2 and Skin Pigmentation
MT-2 is widely recognized for its ability to stimulate melanin production, offering a “sunless tanning” effect. It works by activating melanocortin receptors, primarily MC-1R and MC-4R, which play key roles in skin darkening and other physiological processes. MC-1R is found in skin melanocytes and is responsible for melanin synthesis, while MC-4R influences sexual arousal and appetite regulation.

Important Note: While MT-2 can promote tanning without sun exposure, its long-term safety profile remains under investigation. There is potential concern that it may stimulate the growth of existing skin cancer cells. Always consult a healthcare professional before use.

Melanotan 2 and Weight Management
Research indicates that MT-2 may help reduce fat storage and suppress appetite. It mimics the effects of leptin, a hormone that regulates hunger and energy balance. By activating the MC-4R pathway and increasing thyrotropin-releasing hormone (TRH) expression, MT-2 promotes feelings of fullness and reduces caloric intake. Animal studies have shown that MT-2 decreases dietary fat consumption, making it a promising candidate for weight management research.

MT-2 and Impulse Control
MT-2 has shown potential in reducing addictive behaviors and improving impulse control. Studies on animal models suggest that it can decrease alcohol consumption and increase water intake. When combined with Naltrexone, MT-2 significantly reduces alcohol cravings, highlighting its potential as a therapeutic agent for addiction management.

Melanotan 2 and Autism Spectrum Disorder
In preclinical studies, MT-2 has demonstrated the ability to reverse certain ASD-related behaviors. It enhances oxytocin receptor expression, which is linked to improved social interaction and communication while reducing repetitive behaviors. These findings suggest a potential role for MT-2 in addressing neurological and behavioral aspects of ASD.

MT-2 for Libido and Erectile Dysfunction
MT-2 has been studied for its ability to enhance sexual arousal and treat erectile dysfunction (ED). In clinical trials, it has shown an 80% success rate in cases where other ED medications failed. Unlike traditional ED drugs, MT-2 acts on the central nervous system, offering a broader range of therapeutic effects for both men and women experiencing sexual desire disorders.

Melanotan 2 and Neurodegenerative Diseases
Emerging research suggests that MT-2 may have neuroprotective properties. In studies on Alzheimer’s disease, MT-2 has been shown to reduce beta-amyloid accumulation and decrease neurotoxic reactive astrocytes, which are associated with neuron death. While more research is needed, these findings indicate potential applications for MT-2 in combating neurodegenerative conditions.

Product Details

• CAS Number: 121062-08-6
• Molecular Formula: C50H69N15O9
• Sequence: Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Molar Mass: 1,024.18 g/mol
• Half-Life: Approximately 2 hours
• Purity: Minimum 96% (includes stabilizing agents)
• Form: Lyophilized powder in a sterile glass vial
• Dosage: 10mg per vial
• Storage: Refrigerate after reconstitution

Disclaimer: This product is intended solely for in vitro research purposes by qualified professionals. It is not approved for human or animal consumption, nor is it classified as a drug, supplement, or cosmetic.

References

1. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS One. 2019.
2. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J Endocrinol. 2007.
3. Melanocortin activity in the amygdala influences alcohol intake. Pharmacol Biochem Behav. 2011.
4. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction. J Urol. 1998.
5. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021.