RAD-140 & Cardarine

(18-35 year old demographic)

Liquid RAD-140 (Testolone) Overview – Elitebiogenix.com

RAD-140, commonly referred to as Testolone, is a cutting-edge selective androgen receptor modulator (SARM) originally designed as a potential alternative to traditional testosterone replacement therapies. Distinct from its esterified counterpart, RAD-150 (TLB-150), RAD-140 selectively binds to androgen receptors (AR) without triggering the full spectrum of androgenic effects associated with testosterone, DHT, or anabolic steroids. This unique mechanism makes it a popular choice for research purposes, particularly in studies focused on muscle growth, neuroprotection, and cellular health.

Why RAD-140 Stands Out: High AR Binding Affinity

RAD-140 boasts an exceptional affinity for androgen receptors (AR), with a Ki value of 7 nM, surpassing even DHT and many anabolic steroids. For comparison, testosterone has an AR affinity of 29 nM, while DHT registers at 10 nM. Unlike traditional anabolic agents, RAD-140 is orally bioavailable, eliminating the need for injections. This feature, combined with its potent anabolic properties, has made it a standout SARM for researchers exploring muscle mass enhancement and lean body composition.

Developed in 2010, RAD-140 was initially studied for its potential in treating osteoporosis and promoting muscle growth. Subsequent preclinical trials on primates and rodents, as well as clinical studies, have revealed additional therapeutic benefits, further solidifying its position as a versatile research compound.

RAD-140 and Muscle Growth: What Research Shows

A study involving young male cynomolgus monkeys examined the effects of RAD-140 over 28 days at doses of 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg daily. The results showed a 10% increase in body weight in the 0.1 mg/kg and 1 mg/kg groups, with no additional benefits observed at higher doses. Notably, muscle mass increased significantly in these groups, while body fat remained unchanged. Importantly, there were no adverse effects on liver enzymes or prostate weight, highlighting RAD-140’s selective action on muscle tissue.

Neuroprotective Benefits of RAD-140

RAD-140 has demonstrated promising neuroprotective properties in both in vitro and in vivo studies. A 2014 study found that RAD-140 prevented cell death and restored mitochondrial membrane potential in cultured neurons. In animal models, it significantly reduced seizure activity in male rats with kainate-induced lesions, suggesting potential applications in treating neurological disorders.

Additionally, RAD-140 has shown promise in addressing cognitive decline. Research indicates that androgens, including RAD-140, can inhibit neuronal apoptosis and improve cognitive function, particularly in Alzheimer’s disease (AD) models. By activating rapid phosphoinositide 3-kinase/Akt signaling, RAD-140 regulates proteins linked to apoptosis, such as bax, seladin 1, survivin, XIAP, and bcl-xl, offering a potential pathway for neuroprotection.

RAD-140 and Cellular Protection

Studies have also explored RAD-140’s role in cellular protection. In animal models, RAD-140 replicated the muscle growth benefits of testosterone at half the androgenic activity, making it a safer alternative for research purposes. Its ability to protect neurons and reduce seizure activity further underscores its potential in treating neurodegenerative conditions.

RAD-140 and Breast Cancer: A Promising Avenue

A 2017 study investigated RAD-140’s effects on AR/ER+ breast cancer cells. The results were groundbreaking: RAD-140 significantly inhibited cancer cell growth and metastasis without disrupting the cell cycle. Unlike traditional anti-estrogens and aromatase inhibitors, RAD-140 operates through distinct mechanisms, offering a novel therapeutic approach for hormone-sensitive breast cancers. While more research is needed, these findings position RAD-140 as a potential game-changer in oncology.

Mechanism of Action: How RAD-140 Works

RAD-140’s mechanism of action is multifaceted, offering a range of potential benefits in preclinical studies:

• Increased lean muscle mass and protein synthesis
• Enhanced fat loss and body recomposition
• Neuroprotection and reduced beta-amyloid plaques
• Potential anti-cancer properties
• Improved endurance and recovery

It’s important to note that RAD-140 is not approved by the FDA for human use and is strictly intended for laboratory research. Anecdotal reports suggest potential side effects, including testosterone suppression, nausea, and mild hair loss, though further studies are needed to confirm these findings.

Potential Side Effects of RAD-140

While RAD-140 is generally well-tolerated in research settings, some studies have reported side effects such as nausea, aggression, and reduced natural testosterone levels. A case study highlighted drug-induced liver injury in a subject using RAD-140 alongside antidepressants, though the sample size and lack of controls limit the conclusions. As with all SARMs, RAD-140 may suppress natural testosterone production, emphasizing the need for cautious use in research contexts.

Liquid RAD-140 Specifications – Elitebiogenix.com

• CAS Number: 1182367-47-0
• Molecular Formula: C20H16ClN5O2
• Molar Mass: 393.83 g/mol
• Half-Life: 44.7 hours
• Class: Selective Androgen Receptor Modulator (SARM)
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Each 30ml bottle contains 20 mg/ml of RAD-140, accompanied by a graduated 1mL glass pipette for precise measurement. The UV-resistant glass bottle and tamper-proof seal ensure product integrity and safety during transit. With less than 5% variance in concentration, Elitebiogenix guarantees consistency and quality in every batch.

Disclaimer:
RAD-140 is intended solely for laboratory research purposes and is not approved for human consumption. It is not a dietary or sports supplement. Elitebiogenix adheres to strict quality standards to provide researchers with reliable, high-quality compounds for scientific exploration.

References:

1. Design, Synthesis, and Preclinical Characterization of RAD140 – PubMed
2. Neuroprotective Effects of RAD140 – Endocrinology Journal
3. RAD140 and Breast Cancer – Clinical Cancer Research
4. Androgens and Cognitive Function – Endocrinology Journal
5. Drug-Induced Liver Injury and SARMs – Hepatology Journal

Explore the potential of RAD-140 with Elitebiogenix – your trusted source for premium research compounds.

(18-35 year old demographic)

Liquid Cardarine (GW501516) Overview – Elitebiogenix.com

Cardarine, scientifically known as GW501516 or Endurobol, is a potent PPAR (peroxisome proliferator-activated receptor) agonist. This compound functions as a ligand-activated transcription factor, binding to receptors in skeletal muscle and adipose tissue, promoting lipid utilization and fat burning. PPARs are also integral to processes like inflammation regulation, glucose homeostasis, and cellular functions such as proliferation, differentiation, and apoptosis, hinting at potential anti-aging benefits [1].

PPARs are predominantly found in tissues with high metabolic activity, including skeletal muscle, liver, heart, kidneys, and intestines [13]. Although often mistakenly grouped with selective androgen receptor modulators (SARMs), GW501516 operates differently. It does not interact with androgen receptors or influence testosterone levels but plays a significant role in energy metabolism.

How Cardarine Works

Developed in the 1990s, Cardarine is also referred to as GW1516 and GSK-516. It exhibits strong affinity (Ki = 1 nM) and specificity for PPARδ, with over 1,000-fold selectivity compared to PPARα and PPARγ [5]. When GW501516 binds to PPARδ, it recruits the coactivator PGC-1α, forming a complex that enhances the expression of proteins involved in energy expenditure [6]. By activating AMP-activated protein kinase, Cardarine is believed to offer a range of experimental benefits, including:

• Boosting fatty acid oxidation and fat loss
• Reducing LDL (“bad”) cholesterol
• Increasing HDL (“good”) cholesterol
• Enhancing endurance and stamina
• Lowering inflammation
• Improving insulin sensitivity and glucose tolerance

The Role of PPAR Agonists

Research shows that PPAR activity helps preserve glucose for critical tissues like the brain while mobilizing fatty acids for muscle endurance [10]. PPARs also regulate temperature, inflammation, mitochondrial respiration, and tissue repair. Molecular studies indicate that PPARs control genes linked to lipid oxidation, mitochondrial biogenesis, and contractile proteins [10].

PPAR Effects During Fasting

PPARs are particularly active during fasting, when free fatty acids are released into the bloodstream. Studies on PPAR-null mice revealed that the absence of PPAR leads to elevated free fatty acids, lipid accumulation in the liver and heart, low blood sugar, reduced body temperature, ketone production, and premature death [14]. Mice adapt to fasting by upregulating PPAR genes, which enhance fatty acid uptake and oxidation [15].

Cardarine Research Findings

Numerous animal studies highlight Cardarine’s potential to improve energy metabolism and blood lipid profiles:

• A study on mice demonstrated that GW501516 enhances fatty acid oxidation and alleviates metabolic syndrome [1].
• Research on Kunming mice showed that PPAR activation significantly boosts running endurance [2].
• Another study found that PPARs prevent glucose depletion during exercise, delaying fatigue [3].
• In obese rhesus monkeys, GW501516 increased HDL and reduced VLDL, suggesting cardioprotective effects [6].
• Phase II clinical trials indicated Cardarine’s potential benefits for obesity, diabetes, dyslipidemia, and cardiovascular health, along with reduced inflammation [7, 8].
• A study on high-fructose-fed rats found that GW501516 lowered inflammation markers and upregulated genes involved in beta-oxidation [11].

Cardarine Side Effects

While Cardarine does not cause androgenic side effects like steroids, high doses (3mg/kg/day) in rats led to rapid cancer development in multiple organs [9]. Anecdotal reports suggest minimal side effects, but further research is needed to establish its safety profile. The FDA has not approved Cardarine for human use, and it is banned by the World Anti-Doping Agency (WADA) due to its endurance-enhancing properties [4].

Liquid Cardarine Specifications

• CAS Number: 317318-70-0
• Formula: C21H18F3NO3S2
• Molar Mass: 453.498 g/mol
• Half-Life: 16–24 hours
• Class: PPAR Agonist
• Storage: Store in a cool, dry place away from sunlight to maintain potency.

Product Details:

• 30ml liquid Cardarine per bottle (20mg/ml concentration)
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for secure delivery
• Less than 5% concentration variance for consistency
• Formulated to prevent evaporation during storage

Important Note:
This product is strictly for laboratory research purposes and is not approved by the FDA for human consumption. Cardarine (GW501516) is not a dietary or sports supplement.

Scientific References:

1. Tanaka et al., Proc. Natl. Acad. Sci. U.S.A., 2003
2. Chen et al., Sci. Rep., 2015
3. Fan et al., Cell Metab., 2017
4. Sports Technology Labs, 2023
5. Oliver et al., Proc. Natl. Acad. Sci. U.S.A., 2001
6. Sprecher, Am J Cardiol., 2007
7. Barish et al., J Clin Invest., 2006
8. Dressel et al., Mol Endocrinol., 2003
9. Sahebkar et al., Expert Opin Pharmacother., 2014
10. Coll et al., Endocrinology, 2010
11. Magliano et al., Endocrine, 2015
12. Van Wagoner et al., JAMA, 2017
13. Burri et al., PPAR Res., 2010
14. Leone et al., Proc. Natl. Acad. Sci. U.S.A., 1999
15. Kersten et al., J Clin Invest., 1999