SR-9009 & Cardarine

(18-35 year old demographic)

SR9009 (Liquid Stenabolic) – EliteBiogenix Research Compound Overview

EliteBiogenix is proud to provide premium-quality SR9009 (Liquid Stenabolic), a cutting-edge research compound designed for scientific exploration. SR9009 is a potent Rev-ErbA protein agonist, a protein expressed in key areas of the body, including the liver and skeletal muscle systems. Research indicates that SR9009 plays a significant role in regulating circadian rhythms, influencing lipid and glucose metabolism, and modulating fat-storing cells. While not classified as a SARM (Selective Androgen Receptor Modulator), SR9009 binds to Rev-ErbA, producing effects comparable to SARMs and beyond.

Developed in 2013 by Scripps Research, SR9009 has demonstrated remarkable potential in preclinical studies. Early research on mice revealed its ability to enhance metabolic activity, promote skeletal muscle growth, and support fat loss without impacting endogenous testosterone levels. For researchers seeking a high-quality compound for cutting-edge studies, EliteBiogenix is the trusted source to buy SR9009 online.

Key Research Findings on SR9009

SR9009 has shown a wide range of effects in preclinical studies, including:

• Boosted Resting Metabolic Rate: Enhances energy expenditure, supporting fat loss.
• Cardiovascular Protection: Promotes heart health and resilience under stress.
• Circadian Rhythm Regulation: Helps regulate sleep patterns and metabolic cycles.
• Improved Endurance: Increases exercise capacity and stamina.
• Weight Management: Supports fat reduction and lean muscle retention.
• Cholesterol Regulation: Lowers cholesterol levels for improved metabolic health.
• Anti-Inflammatory Properties: Reduces bodily inflammation.
• Arterial Health: Manages arterial plaque buildup.

SR9009 has also shown promise in addressing conditions such as heart failure, COPD (Chronic Obstructive Pulmonary Disease), and metabolic syndrome. However, further research on human subjects is required to fully understand its potential.

SR9009 and Circadian Rhythm

SR9009 has been shown to influence circadian behavior and gene expression in preclinical models. By targeting Rev-ErbA, it modulates metabolic genes in the liver, skeletal muscle, and adipose tissues, leading to increased energy expenditure. In studies involving diet-induced obese mice, SR9009 reduced fat mass, improved dyslipidemia, and normalized hyperglycemia. These findings suggest that SR9009 may hold potential for addressing sleep disorders and metabolic diseases linked to circadian rhythm disruptions.

SR9009 and Energy Metabolism

Research on SR9009 highlights its ability to regulate energy homeostasis. In studies involving goldfish, SR9009 inhibited feeding, reduced body weight, and lowered plasma glucose levels. It also decreased lipid levels and lipogenic enzyme activity while increasing glycolysis in the liver. These effects indicate that SR9009 promotes a negative energy balance by optimizing lipid and glucose metabolism, making it a compelling compound for metabolic research.

SR9009 and Endurance

A 2013 study demonstrated that mice treated with SR9009 exhibited significantly improved endurance, running longer distances and durations compared to untreated subjects. This effect is attributed to SR9009’s ability to increase mitochondrial density and enhance respiratory capacity. Unlike other endurance-enhancing compounds, SR9009 achieves this by regulating gene networks that govern mitochondrial function, offering a unique mechanism of action.

SR9009 and Cardiovascular Health

SR9009 has demonstrated cardio-protective properties in preclinical models. Studies on REV-ERB-deficient mice revealed that SR9009 could still protect the heart from pressure overload, even in the absence of REV-ERB proteins. This suggests that SR9009’s cardio-protective effects operate independently of REV-ERB, making it a valuable compound for cardiovascular research.

SR9009 and Lung Health

In vitro studies have shown that SR9009 can reduce inflammation in lung injury models by suppressing TLR4-induced NF-κB activation. It has also been shown to improve metabolic markers such as arterial PaCO2, PaO2, and blood pH, suggesting potential benefits for acute lung injury management. Additionally, SR9009 has demonstrated anti-tumor effects in small cell lung cancer (SCLC) models, making it a promising candidate for oncology research.

SR9009 (Liquid Stenabolic) Product Details

• CAS Number: 1379686-30-2
• Molecular Formula: C20H24ClN3O4S
• Molar Mass: 437.940 g/mol
• Classification: Rev-ErbA Agonist
• Storage: Store in a cool, dry place away from direct sunlight to maintain stability.

Product Specifications:

• 50ml liquid SR9009 per bottle
• Concentration: 20mg/ml
• Includes a graduated 1mL glass pipette for precise measurement
• UV-resistant glass bottle to minimize degradation
• Tamper-proof seal for secure delivery
• Less than 5% concentration variance for consistency
• Formulated to prevent evaporation during storage

Important Note: SR9009 is intended for laboratory research purposes only. It is not approved by the FDA for human consumption and should not be used as a dietary or sports supplement.

References

1. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature
2. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nature
3. SR9009 improves heart function after pressure overload independent of cardiac REV-ERB. Frontiers in Cardiovascular Medicine
4. SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis. Hindawi
5. SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. NCBI
6. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish. MDPI

(18-35 year old demographic)

LIQUID CARDARINE (GW501516) OVERVIEW

Cardarine, also known as GW501516 or Endurobol, is a PPAR (peroxisome proliferator-activated receptor) agonist and ligand-activated transcription factor that binds to receptors in skeletal muscle tissue and body fat and pushes skeletal muscle cells towards preferential lipid utilization and fat burning. PPAR is also involved in inflammation, glucose homeostasis, as well as cell proliferation, differentiation, and apoptosis, suggesting potential anti-aging effects of PPAR agonists [1].

PPAR are located in greatest concentration in tissues with high metabolic rates like skeletal muscle, intestine, liver, heart, and kidney [13]. GW-501516 is often wrongly classified as a selective androgen receptor modulator (SARM). As a PPAR, it shares certain commonalities with SARMs but differs from them in a few important ways. GW 501516 does not affect androgen receptors or alter testosterone levels however it does have a key involvement in energy metabolism.

CARDARINE MECHANISM OF ACTION

Invented in the early 1990s, Cardarine is also known by a number of alternate names, including GW1516 and GSK-516. It displays high affinity (Ki = 1 nM) and potency for PPARδ with over 1,000-fold selectivity over PPARα and PPARγ [5]. Binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure [6]. By activating AMP-activated protein kinase, it is widely believed to provide a broad range of experimental effects currently being tested in research such as:

• Increases fatty acid oxidation and promotes fat loss
• Lower LDL cholesterol (“bad cholesterol”)
• Higher HDL cholesterol (“good cholesterol”)
• Increases endurance
• Reduces inflammation
• Decreases insulin resistance and improves glucose tolerance

FUNCTION OF PPAR AGONISTS

Data indicates that PPAR activity preserves glucose for use in tissues like the brain while promoting the mobilization of fatty acids for muscular endurance [10]. PPAR has also been observed playing an important role in temperature regulation, inflammation mediation, mitochondrial respiration, keratinocyte differentiation, and skin and muscle repair. Molecular analyses revealed that PPAR regulates the expression of genes associated with contractile proteins, lipid oxidation, and mitochondrial biogenesis [10].

PPAR EFFECTS DURING FASTING

The effects of PPAR are observed in particular during fasting, when free fatty acids are released into the blood. A study in PPAR-null mice demonstrated that the absence of PPAR results in elevated free fatty acids during fasting, lipid accumulation in the liver and heart, low blood sugar, low body temperature, ketones in urine, and ultimately a premature death [14]. Mice naturally adapt to high free fatty acid levels during fasting through induction of cardiac and hepatic PPAR genes that improve fatty acid uptake and oxidation [15].

The benefits and side effects of GW501516 however, have not been confirmed by the Food and Drug Administration (FDA) and like other SARMs for sale, it should be used for research purposes only. Due to its tendency to increase endurance and energy, the World Anti Doping Agency (WADA) has banned the use of Cardarine in professional sports and several athletes have tested positive for Cardarine and were dismissed as this chemical is only for researchers and clinical trials [4].

STUDIES INCLUDING CARDARINE

A number of animal studies have been performed that point to Cardarine’s ability to enhance certain physiological processes related to energy metabolism as well as potential improvements in blood lipids:

• One study on mice found that GW501516 promotes fatty acid oxidation and fat burning in skeletal muscle tissue and alleviates metabolic syndrome [1].
• Another study discovered that peroxisome proliferator-activated receptors can markedly increase running endurance in Kunming mice [2].
• Yet another study on mice revealed that PPARs augment exercise endurance by preventing exhaustion of glucose (“hitting the wall”) [3].
• A study involving obese rhesus monkeys found that GW 501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL), indicating potential cardioprotective effects from Cardarine [6].
• Two separate phase II clinical studies found positive effects of Cardarine on obesity, diabetes, dyslipidemia, and cardiovascular disease, as well as suppression in macrophage-derived inflammation [7, 8].
• A study in rats that were fed a high fructose diet found that GW 501516 reduced inflammation markers, especially in the liver, and increased the expression of genes that regulate beta-oxidation [11].

SIDE EFFECTS OF CARDARINE

While Cardarine is not known to cause androgenic side effects like anabolic androgenic steroids, data in rats indicates that doses of 3mg/kg/day (180-240mg per day in the average 60-80kg adult), significantly higher than those used in mammalian trails, caused cancer to develop quickly in several organs [9]. Anecdotal data online indicates little in the way of noticeable side effects but more research is necessary to determine the overall safety profile of GW501516 before it can be approved for human use by the FDA.

LIQUID CARDARINE DATA

• 50ml Liquid Cardarine per bottle with 10 milligrams per milliliter.
• Includes graduated 1mL glass pipette for convenient measurement.
• Glass bottle with UV resistance to minimize degradation.
• Tamper-proof seal to ensure safety in transit.
• Less than 5% variance in concentration, guaranteeing consistency.
• Formulated and packaged to prevent evaporation in storage.

This preparation is for laboratory research purposes only and is not approved by the FDA for human consumption. Cardarine / GW501516 IS NOT A DIETARY OR SPORTS SUPPLEMENT.